Compared to other databases, RNArchitecture is unique in its focus on structure-based RNA classification, and in providing a platform for storing RNA 3D structure predictions. RNArchitecture also presents theoretical models of RNA 3D structure and is open for submission of structural models by users. For each Family with an experimentally determined 3D structure(s), a representative one is provided. Some groups at different levels of the hierarchy are currently labeled as “unclassified”. The highest level, Class, organizes Families into very broad structural categories, such as simple or complex structured RNAs. Similar structures are further grouped into Architectures. Evolutionarily related Families are grouped into Superfamilies. Consensus structures of Families are described with a reduced secondary structure representation.
Its central level is Family, which builds on the Rfam catalog, and gathers closely related RNAs. The classification is hierarchical and similar to the system used in the SCOP and CATH databases of protein structures.
RNArchitecture is a database that provides a comprehensive description of relationships between known families of structured non-coding RNAs, with a focus on structural similarities.
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